rospedjРоссийский педиатрический журналRussian Pediatric Journal2687-0843Издательство «ПедиатрЪ»10.15690/rpj.v1i3.2170rospedj-65Research ArticleОБЗОР ЛИТЕРАТУРЫREVIEWЭхоструктурные и функциональные особенности органов и систем у детей с низкой, очень низкой и экстремально низкой массой тела при рождении (обзор литературы)The echographic characteristics of structural and functional development of organs and systems in children born with low birth weight, very low birth weight and extremely low birth weighthttps://orcid.org/0000-0001-7639-1747ХодкевичП. Е.KhodkevichP. E.

Ходкевич Полина Евгеньевна, аспирант кафедры факультетской педиатрии с курсом детских болезней лечебного факультета

634050, Томск, Московский тракт, д. 2+7 (952) 883-36-68 

Tomsk

pkhodkevich@mail.ruhttps://orcid.org/0000-0001-8926-5918КуликоваК. В.КulikovaK. V.

Томск

Tomsk

https://orcid.org/0000-0001-8272-3648ГоревВ. В.GorevV. V.

Москва

Moscow

https://orcid.org/0000-0002-4449-4810ДеевИ. А.DeevI. A.

Томск

Tomsk

Сибирский государственный медицинский университет Министерства здравоохранения Российской ФедерацииРоссияSiberian State Medical University, the Ministry of Healthcare of the Russian FederationRussian FederationСибирский государственный медицинский университет Министерства здравоохранения Российской Федерации; Областной перинатальный центр им. И. Д. ЕвтушенкоРоссияSiberian State Medical University, the Ministry of Healthcare of the Russian Federation; I.D. Evtushenko Regional Perinatal CenterRussian FederationМорозовская детская городская клиническая больницаРоссияMorozov Children’s City Clinical HospitalRussian Federation202026112020131117Copyright © Ходкевич П.Е., Куликова К.В., Горев В.В., Деев И.А., 20202020Ходкевич П.Е., Куликова К.В., Горев В.В., Деев И.А.Khodkevich P.E., Кulikova K.V., Gorev V.V., Deev I.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rospedj.ru/jour/article/view/65

В последнее десятилетие на территории Российской Федерации отмечается рост выживаемости детей с низкой, очень низкой и экстремально низкой массой тела при рождении, что определено в том числе переходом на новые критерии живорожденности. Недоношенные дети подвергаются действию ряда неблагоприятных факторов, которые оказывают негативное влияние на развитие органов и систем, что, в свою очередь, может приводить к возникновению острых и хронических заболеваний в различные возрастные периоды. Таким образом, неонатологи и педиатры столкнулись с новой когортой маловесных детей, которые имеют особенности физического и нервно-психического развития, тяжелые инвалидизирующие заболевания, а также особенности функционирования внутренних органов и систем. В статье представлен обзор литературных данных относительно результатов исследований, оценивавших эхоструктурные и функциональные характеристики мочевыделительной, сердечно-сосудистой и эндокринной систем в зависимости от массы тела при рождении и срока гестации в разные возрастные периоды.

Over the past decade, an increase in the survival rate of children born with low birth weight, very low birth weight, and extremely low birth weight has been observed in Russian Federation, which is due to transition to new live birth criteria. Premature infants are exposed to a number of adverse factors that have a negative impact on the development of organs and systems, which, in turn, can lead to the occurrence of acute and chronic diseases in various age periods. Therefore, neonatologists and pediatricians are dealing with a new cohort of small children who have particular features of physical and neuropsychological development which may lead to severe debilitating diseases. This review article surveys previous studies evaluating the echographic characteristics of structural and functional development of the urinary, cardiovascular and endocrine systems as a function of body weight at birth and gestational age, and in different age periods.

недоношенные детиочень низкая масса телаэкстремально низкая масса телапреждевременные родыфункциональные особенности органов и системpremature babiesvery low body weightpremature birthextremely low body weightfunctional development of organs and systemsReferencesNuyt AM, Lavoie JC, Mohamed I, et al. Adult Consequences of Extremely Preterm Birth: Cardiovascular and Metabolic Diseases Risk Factors, Mechanisms, and Prevention Avenues. Clin Perinatol. 2017;44(2):315–332. doi: 10.1016/j.clp.2017.01.010.Nuyt AM, Lavoie JC, Mohamed I, et al. Adult Consequences of Extremely Preterm Birth: Cardiovascular and Metabolic Diseases Risk Factors, Mechanisms, and Prevention Avenues. Clin Perinatol. 2017;44(2):315–332. doi: 10.1016/j.clp.2017.01.010.Баранов А. А. Актуальные проблемы охраны здоровья детей // Здравоохранение России: федеральный справочник. 2013. — Т. 14. — С. 169–172.Baranov AA. Zdravookhranenie Rossii: federal’nyi spravochnik. 2013;14:169–172. (In Russ).Профилактическая педиатрия: руководство для врачей / под ред. А. А. Баранова. М.: Союз педиатров России; 2012.Profilakticheskaya pediatriya: rukovodstvo dlya vrachei. Baranov АA, ed. Мoscow: Soyuz pediatrov Rossii; 2012. (In Russ).Преждевременные роды: информационный бюллетень ВОЗ. 19 февраля 2018. Режим доступа: https://www.who.int/ru/news-room/fact-sheets/detail/preterm-birth. Дата обращения 12.06.2020.Preterm birth: WHO Fact sheet. 19 February 2018. (In Russ). Режим доступа: https://www.who.int/ru/news-room/fact-sheets/detail/preterm-birth. Дата обращения 12.06.2020.Скрипниченко Ю. П., Баранов И. И., Токова З. З. Статистика преждевременных родов // Проблемы репродукции. — 2014. № 4. — С. 11–14.Skripnichenko YuP, Baranov II, Tokova ZZ. Statistics of the preterm births. Russian Journal of Human Reproduction = Problemy reproduktsii. 2014;4:11–14. (In Russ).Handbook of Life Course Health Development. Halfon N, Forrest CB, Lerner RM, Faustman EM, еds. Cham (CH): Springer; 2018.Handbook of Life Course Health Development. Halfon N, Forrest CB, Lerner RM, Faustman EM, еds. Cham (CH): Springer; 2018.Salt A., Ahluwalia J., East M. Outcome at two years of very low birth weight infants in the East Anglian region: 1993–1997. Arch Dis Child. 2002;86(Suppl 1): A30–A32. doi: 10.1136/adc.86.suppl_1.A30.Salt A., Ahluwalia J., East M. Outcome at two years of very low birth weight infants in the East Anglian region: 1993–1997. Arch Dis Child. 2002;86(Suppl 1): A30–A32. doi: 10.1136/adc.86.suppl_1.A30.Деев И. А., Куликова К. В., Кобякова О. С. и др. Клиническая характеристика новорожденных с различной массой тела при рождении (результаты многоцентрового когортного исследования) // Педиатрия. — 2016. — Т. 7. — № 4. — С. 67–76. doi: 10.17816/PED7467-76.Deev I A, Kulikova K V, Kobyakova O S, et al. Clinical characteristics of newborn with different birth weight (results of a multicenter cohort study). Pediatrician. 2016;7(4):67–76. (In Russ). doi: 10.17816/PED7467-76.Курец Н. И. Низкая масса тела при рождении и отдаленные последствия // Репродуктивное здоровье. Восточная Европа. 2012. — Т. 2. — № 20. — С. 87–112.Kurets N I. Low birth weight and long-term effects. Reproductive health. Eastern Europe. 2012;2(20):87–112. (In Russ).Chehade H, Simeoni U, Guignard JP, Boubred F. Preterm Birth: Long Term Cardiovascular and Renal Consequences. Curr Pediatr Rev. 2018;14(4):219–226. doi: 10.2174/1573396314666180813121652.Chehade H, Simeoni U, Guignard JP, Boubred F. Preterm Birth: Long Term Cardiovascular and Renal Consequences. Curr Pediatr Rev. 2018;14(4):219–226. doi: 10.2174/1573396314666180813121652.Мухин Н. А. Снижение скорости клубочковой фильтрации — общепопуляционный маркер неблагоприятного прогноза // Терапевтический архив. — 2007. — № 6. — С. 5–10.Mukhin NА. Decreased glomerular filtration rate is a common population marker for poor prognosis. Therapeutic Archive. 2007;(6):5–10. (In Russ).Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO. Clinical Practice Guideline for Acute Kidney Injury. Kidney Int Suppl. 2012;2(1):1–138. doi: 10.1038/kisup.2012.1.Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO. Clinical Practice Guideline for Acute Kidney Injury. Kidney Int Suppl. 2012;2(1):1–138. doi: 10.1038/kisup.2012.1.Абдуллина Г. А., Сафина А. И., Даминова М. А. Клиническая физиология почек у недоношенных: роль динамического наблюдения // Вестник современной клинической медицины. 2014. — Т. 7. — № 6. — С. 9–13.Abdullina GA, Safina АI, Daminova МА. Clinical physiology of the kidneys in premature: the role of followup. Bulletin of modern clinical medicine. 2014; 7(6):9–13. (In Russ).Keijzer-Veen MG, Schrevel M, Finken MJJ, et al. Microalbuminuria and lower glomerular filtration rate at young adult age in subjects born very premature and after intrauterine growth retardation. Am Soc Nephrol. 2005;16(9):2762–2768. doi: 10.1681/ASN.2004090783.Keijzer-Veen MG, Schrevel M, Finken MJJ, et al. Microalbuminuria and lower glomerular filtration rate at young adult age in subjects born very premature and after intrauterine growth retardation. Am Soc Nephrol. 2005;16(9):2762–2768. doi: 10.1681/ASN.2004090783.Mackenzie HS, Brenner BM. Fewer nephrons at birth: a missing link in the etiology of essential hypertension. Am Kidney Dis. 1995;26(1):91–98. doi: 10.1016/0272-6386(95)90161-2.Mackenzie HS, Brenner BM. Fewer nephrons at birth: a missing link in the etiology of essential hypertension. Am Kidney Dis. 1995;26(1):91–98. doi: 10.1016/0272-6386(95)90161-2.Rodríguez MM, Gómez AH, Abitbol CL, et al. Histomorphometric analysis of postnatal glomerulogenesis in extremely preterm infants. Pediatr Dev Pathol. 2004;7(1):17–25. doi: 10.1007/s10024-0033029-2.Rodríguez MM, Gómez AH, Abitbol CL, et al. Histomorphometric analysis of postnatal glomerulogenesis in extremely preterm infants. Pediatr Dev Pathol. 2004;7(1):17–25. doi: 10.1007/s10024-0033029-2.Ciccone MM, Cortese F, Gesualdo M, et al. The role of very low birth weight and prematurity on cardiovascular disease risk and on kidney development in children: a pilot study. Minerva Pediatr. 2016;72(3):149–158. doi: 10.23736/S0026-4946.16.04520-5.Ciccone MM, Cortese F, Gesualdo M, et al. The role of very low birth weight and prematurity on cardiovascular disease risk and on kidney development in children: a pilot study. Minerva Pediatr. 2016;72(3):149–158. doi: 10.23736/S0026-4946.16.04520-5.Keijzer-Veen MG, Devos AS, Meradji M, et al. Reduced renal length and volume 20 years after very preterm birth. Pediatr Nephrol. 2010;25(3):499–507. doi: 10.1007/s00467-009-1371-y.Keijzer-Veen MG, Devos AS, Meradji M, et al. Reduced renal length and volume 20 years after very preterm birth. Pediatr Nephrol. 2010;25(3):499–507. doi: 10.1007/s00467-009-1371-y.Сафина А. И., Абдуллина Г. А., Даминова М. А. Формирование хронической болезни почек у детей раннего возраста, родившихся глубоко недоношенными // Педиатрия. — 2016. — Т. 95. № 5. — С. 8–14.Safina A. I., Abdullina G. A., Daminova M. A. Chronic kidney disease formation in infants born deeply preterm. Pediatria. 2016;95(5):8–14. (In Russ).Зернова Л. Ю., Коваленко Т. В. Особенности гормональной адаптации новорожденных с экстремально низкой массой тела // Охрана здоровья матери и ребенка. — 2016. Т. 54. — С. 113–115.Zernova LYu, Kovalenko T V. Osobennosti gormonal’noi adaptatsii novorozhdennykh s ekstremal’no nizkoi massoi tela. Okhrana zdorov’ya materi i rebenka. 2016;54:113–115. (in Russian)Лебедева О. В. Оптимизация диагностики, прогнозирования и профилактики перинатальных осложнений у детей с очень низкой и экстремально низкой массой тела при рождении: автореф. дис. … докт. мед. наук. — М.; 2015. 46 с.Lebedeva O V. Optimizatsiya diagnostiki, prognozirovaniya i profilaktiki perinatal’nykh oslozhnenii u detei s ochen’ nizkoi i ekstremal’no nizkoi massoi tela pri rozhdenii. [abstract of dissertation]. Мoscow; 2015. 46 p. (In Russ).Posod A., Komazec IO, Peglow UP, et al. Former Very Preterm Infants Show Alterations in Thyroid Function at a Preschool Age. Biomed Res Int. 2017;2017:3805370. doi: 10.1155/2017/3805370.Posod A., Komazec IO, Peglow UP, et al. Former Very Preterm Infants Show Alterations in Thyroid Function at a Preschool Age. Biomed Res Int. 2017;2017:3805370. doi: 10.1155/2017/3805370.Kormaz G, Ozcetin M, Cag Y, et al. Thyroid function in healthy and unhealthy preterm newborns. Afr Health Sci. 2018; 18(2):378–383. doi: 10.4314/ahs.v18i2.23.Kormaz G, Ozcetin M, Cag Y, et al. Thyroid function in healthy and unhealthy preterm newborns. Afr Health Sci. 2018; 18(2):378–383. doi: 10.4314/ahs.v18i2.23.Kilchemmann FC, Roman NA, Navarrete RM, Fuentes BD. Thyroid hormone Levels in very preterm neonates and extremely preterm. Rev Chil Pediatr. 2018; 89(2):202–207. doi: 10.4067/S0370-41062018000200202.Kilchemmann FC, Roman NA, Navarrete RM, Fuentes BD. Thyroid hormone Levels in very preterm neonates and extremely preterm. Rev Chil Pediatr. 2018; 89(2):202–207. doi: 10.4067/S0370-41062018000200202.Aktas ON, Gursoy T, Soysal E, et al. Thyroid hormone levels in late preterm, early term and term infants: a study with healthy neonates revealing reference values and factors affecting thyroid hormones. Pediatr Endocrinol Metab. 2017;30(11):1191–1196. doi: 10.1515/jpem-2017-0215.Aktas ON, Gursoy T, Soysal E, et al. Thyroid hormone levels in late preterm, early term and term infants: a study with healthy neonates revealing reference values and factors affecting thyroid hormones. Pediatr Endocrinol Metab. 2017;30(11):1191–1196. doi: 10.1515/jpem-2017-0215.Мараховская В. С., Козачук С. А., Зеленская А. А., Шацких Н. С. Обеспеченность гормонами гипофизарно-тиреоидной системы глубоко недоношенных новорожденных детей // Украинский морфологический альманах имени профессора В. Г. Ковешникова. — 2017. — Т. 15. — № 2. — С. 85–87.Marakhovskaya V. S., Kozachuk S. A., Zelenskaya A. A., Shatskikh N. S. Provision with hormones of the pituitarythyroid system of deeply premature newborn. V. G. Koveshnikov Morphological Almanac. 2017;15(2):85–87. (In Russ).Khan SS, Hong-McAtee I, Kriss VM, et al. Thyroid gland volumes in premature infants using serial ultrasounds. J Perinatol. 2018;38(10):1353–1358. doi: 10.1038/s41372-018-0149-0.Khan SS, Hong-McAtee I, Kriss VM, et al. Thyroid gland volumes in premature infants using serial ultrasounds. J Perinatol. 2018;38(10):1353–1358. doi: 10.1038/s41372-018-0149-0.Ng SM, Turner MA, Avula S. Ultrasound Measurements of Thyroid Gland Volume at 36 Weeks’ Corrected Gestational Age in Extremely Preterm Infants Born before 28 Weeks’ Gestation. Eur Thyroid J. 2018;7(1):21–26. doi: 10.1159/000481857.Ng SM, Turner MA, Avula S. Ultrasound Measurements of Thyroid Gland Volume at 36 Weeks’ Corrected Gestational Age in Extremely Preterm Infants Born before 28 Weeks’ Gestation. Eur Thyroid J. 2018;7(1):21–26. doi: 10.1159/000481857.Болмасова А. В., Меликян М. А., Маркова О. Ю., Дегтярева А. В. Транзиторные эндокринопатии у детей, рожденных с низкой и экстремально низкой массой тела // Материалы VIII регионального научного форума «Мать и дитя». — Сочи; 2015. С. 141.Bolmasova AV, Melikyan MA, Markova OYu, Degtyareva AV. Tranzitornye endokrinopatii u detei, rozhdennykh s nizkoi i ekstremal’no nizkoi massoi tela. In: Materialy VIII regional’nogo nauchnogo foruma “Mat’ i ditya”. Sochi; 2015. p. 141. (In Russ).Пыков М. И., Ефимов М. С., Макушева В. Г. Ультразвуковая характеристика надпочечников у новорожденных детей // Эффективная фармакотерапия. — 2011. — № 30. С. 8–15.Pykov MI, Efimov MS, Makusheva VG. Ul’trazvukovaya kharakteristika nadpochechnikov u novorozhdennykh detei. Effektivnaya farmakoterapiya. 2011;(30):8–15. (In Russ).Ng SM, Ogundiya A, Didi M, Turner MA. Adrenal function of extremely premature infants in the first 5 days after birth. Pediatr Endocrinol Metab. 2019;32(4):363–367. doi: 10.1515/jpem-2018-0417.Ng SM, Ogundiya A, Didi M, Turner MA. Adrenal function of extremely premature infants in the first 5 days after birth. Pediatr Endocrinol Metab. 2019;32(4):363–367. doi: 10.1515/jpem-2018-0417.James E, Wood CL, Nair H, Williams TC. Preterm birth and the timing of puberty: a systematic review. BMC Pediatr. 2018;18(1):3. doi: 10.1186/s12887-017-0976-8.James E, Wood CL, Nair H, Williams TC. Preterm birth and the timing of puberty: a systematic review. BMC Pediatr. 2018;18(1):3. doi: 10.1186/s12887-017-0976-8.Wehkalampi K., Hovi P., Dunkel L., et al. Advanced pubertal growth spurt in subjects born preterm: the Helsinki study of very low birth weight adults. Clin Endocrinol Metab. 2011;96(2):525–533. doi: 10.1210/jc.2010-1523.Wehkalampi K., Hovi P., Dunkel L., et al. Advanced pubertal growth spurt in subjects born preterm: the Helsinki study of very low birth weight adults. Clin Endocrinol Metab. 2011;96(2):525–533. doi: 10.1210/jc.2010-1523.Hui LL, Leung GM, Lam TH, Schooling CM. Premature birth and age at onset of puberty. Epidemiology. 2012;23(3):415–422. doi: 10.1097/EDE.0b013e31824d5fd0.Hui LL, Leung GM, Lam TH, Schooling CM. Premature birth and age at onset of puberty. Epidemiology. 2012;23(3):415–422. doi: 10.1097/EDE.0b013e31824d5fd0.Артымук Н. В., Елгина С. И., Никулина Е. Н. Овариальный резерв недоношенных девочек при рождении и в пубертатный период // Фундаментальная и клиническая медицина. 2017. — Т. 2. — № 3. — С. 6–12. doi: 10.23946/2500-0764-2017-2-3-6-12.Artymuk NV, Elgina SI, Nikulina EN. Ovarian reserve in preterm girls at birth and in puberty. Fundamental and clinical medicine. 2017;2(3):6–12. (In Russ). doi: 10.23946/2500-0764-2017-2-3-6-12.Balasuriya CND, Stunes AK, Mosti MP, et al. Outcomes in Adults Born Preterm With Very Low Birthweight or Small for Gestational Age at Term: A Cohort Study. Clin Endocrinol Metab. 2018;103(12):4437–4446. doi: 10.1210/jc.2018-00464.Balasuriya CND, Stunes AK, Mosti MP, et al. Outcomes in Adults Born Preterm With Very Low Birthweight or Small for Gestational Age at Term: A Cohort Study. Clin Endocrinol Metab. 2018;103(12):4437–4446. doi: 10.1210/jc.2018-00464.Huang YT, Lin HY, Wang CH, et al. Association of preterm birth and small for gestational age with metabolic outcomes in children and adolescents: A population-based cohort study from Taiwan. Pediatr Neonatol. 2018;59(2):147–153. doi: 10.1016/j.pedneo.2017.07.007.Huang YT, Lin HY, Wang CH, et al. Association of preterm birth and small for gestational age with metabolic outcomes in children and adolescents: A population-based cohort study from Taiwan. Pediatr Neonatol. 2018;59(2):147–153. doi: 10.1016/j.pedneo.2017.07.007.Sipola-Leppänen M, Vääräsmäki M, Tikanmäki M, et al. Cardiometabolic risk factors in young adults who were born preterm. Am Epidemiol. 2015;181(11):861–873. doi: 10.1093/aje/kwu443.Sipola-Leppänen M, Vääräsmäki M, Tikanmäki M, et al. Cardiometabolic risk factors in young adults who were born preterm. Am Epidemiol. 2015;181(11):861–873. doi: 10.1093/aje/kwu443.Aly H, Soliman RM, El-Dib M, et al. Birth Weight, Insulin Resistance, and Blood Pressure in Late Preterm Infants. Am J Perinatol. 2015;32(9):865–872. doi: 10.1055/s-0034-1543948.Aly H, Soliman RM, El-Dib M, et al. Birth Weight, Insulin Resistance, and Blood Pressure in Late Preterm Infants. Am J Perinatol. 2015;32(9):865–872. doi: 10.1055/s-0034-1543948.Toftlund LH, Halken S, Agertoft L, Zachariassen G. Early nutrition and signs of metabolic syndrome at 6 y of age in children born very preterm. Am Clin Nutr. 2018;107(5):717–724. doi: 10.1093/ajcn/nqy015.Toftlund LH, Halken S, Agertoft L, Zachariassen G. Early nutrition and signs of metabolic syndrome at 6 y of age in children born very preterm. Am Clin Nutr. 2018;107(5):717–724. doi: 10.1093/ajcn/nqy015.Каменская Е. Н. Магниевый статус в диаде «мать-ребенок» при абдоминальном родоразрешении: автореф. дис. … канд. мед. наук. — М.; 2012. — 16 с.Kamenskaya EN. Magnievyi status v diade «mat'-rebenok» pri abdominal'nom rodorazreshenii. [abstract of dissertation]. Мoscow; 2012. 16 p. (In Russ).Dowa Y, Kawai M, Kanazawa H, et al. Screening for secondary hyperparathyroidism in preterm infants. Pediatr Int. 2016;58(10):988–992. doi: 10.1111/ped.12961.Dowa Y, Kawai M, Kanazawa H, et al. Screening for secondary hyperparathyroidism in preterm infants. Pediatr Int. 2016;58(10):988–992. doi: 10.1111/ped.12961.Taylor SN, Wahlquist A, Wagner CL, et al. Functional indicators of vitamin D adequacy for very low birth weight infants. Perinatol. 2018;38(5):550–556. doi: 10.1038/s41372-018-0098-7.Taylor SN, Wahlquist A, Wagner CL, et al. Functional indicators of vitamin D adequacy for very low birth weight infants. Perinatol. 2018;38(5):550–556. doi: 10.1038/s41372-018-0098-7.Shaw JCL. Evidence of defective skeletal mineralization in low birthweight infants: the absorption of calcium and fat. Pediatrics. 1976;57(1):16–25.Shaw JCL. Evidence of defective skeletal mineralization in low birthweight infants: the absorption of calcium and fat. Pediatrics. 1976;57(1):16–25.Нароган М. В., Рюмина И. И., Степанов А. В. Остеопения (метаболическая болезнь костей) у недоношенных: возможности диагностики, лечения и профилактики // Неонатология: новости, мнения, обучение. — 2014. — № 3. — С. 77–83.Narogan MV, Ryumina II, Stepanov AV. Osteopenia (metabolic bone disease) in preterm infants: possibilities of diagnostics, treatment and prevention. Neonatology: news, opinions, training. 2014;(3):77–83. (In Russ)Chinoy A, Mughal MZ, Padidela R. Metabolic bone disease of prematurity: causes, recognition, prevention, treatment and long-term consequences. Arch Dis Child Fetal Neonatal Ed. 2019;104(5):560–566. doi: 10.1136/archdischild-2018-316330.Chinoy A, Mughal MZ, Padidela R. Metabolic bone disease of prematurity: causes, recognition, prevention, treatment and long-term consequences. Arch Dis Child Fetal Neonatal Ed. 2019;104(5):560–566. doi: 10.1136/archdischild-2018-316330.Moreira A, February M, Geary CJ. Parathyroid hormone levels in neonates with suspected osteopenia. Paediatr Child Health. 2013;49(1):12–16. doi: 10.1111/jpc.12052.Moreira A, February M, Geary CJ. Parathyroid hormone levels in neonates with suspected osteopenia. Paediatr Child Health. 2013;49(1):12–16. doi: 10.1111/jpc.12052.Hitrova S, Slancheva B, Popivanova A, et al. Osteopenia of prematurity — prophylaxis, diagnostics and treatment. Akush Ginekol (Sofiia). 2012;51(7):24–30.Hitrova S, Slancheva B, Popivanova A, et al. Osteopenia of prematurity — prophylaxis, diagnostics and treatment. Akush Ginekol (Sofiia). 2012;51(7):24–30.Kowalski RR, Beare R, Doyle LW, et al. Victorian Infant Collaborative Study Group.Elevated Blood Pressure with Reduced Left Ventricular and Aortic Dimensions in Adolescents Born Extremely Preterm. Pediatr. 2016;172:75–80. doi: 10.1016/j.jpeds.2016.01.020.Kowalski RR, Beare R, Doyle LW, et al. Victorian Infant Collaborative Study Group.Elevated Blood Pressure with Reduced Left Ventricular and Aortic Dimensions in Adolescents Born Extremely Preterm. Pediatr. 2016;172:75–80. doi: 10.1016/j.jpeds.2016.01.020.Schmitz L, Stiller B, Pees C, et al. Doppler-derived parameters of diastolic left ventricular function in preterm infants with a birth weight <1500 g: reference values and differences to term infant. Early Hum Dev. 2004;76(2):101–114. doi: 10.1016/j.earlhumdev.2003.11.003.Schmitz L, Stiller B, Pees C, et al. Doppler-derived parameters of diastolic left ventricular function in preterm infants with a birth weight <1500 g: reference values and differences to term infant. Early Hum Dev. 2004;76(2):101–114. doi: 10.1016/j.earlhumdev.2003.11.003.Mazursky JE, Birkett CL, Bedell KA, et al. Development of baroreflex influences on heart rate variability in preterm infants. Early Hum Dev. 1998;53(1):37–52. doi: 10.1016/s03783782(98)00038-3.Mazursky JE, Birkett CL, Bedell KA, et al. Development of baroreflex influences on heart rate variability in preterm infants. Early Hum Dev. 1998;53(1):37–52. doi: 10.1016/s03783782(98)00038-3.Kojima A, Hata T, Sadanaga T, et al. Maturation of the QT Variability Index is Impaired in Preterm Infants. Pediatr Cardiol. 2018;39(5):902–905. doi: 10.1007/s00246-018-1839-2.Kojima A, Hata T, Sadanaga T, et al. Maturation of the QT Variability Index is Impaired in Preterm Infants. Pediatr Cardiol. 2018;39(5):902–905. doi: 10.1007/s00246-018-1839-2.Lim SS, Vos T, Flaxman AD, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2224–2260. doi: 10.1016/S01406736(12)61766-8.Lim SS, Vos T, Flaxman AD, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2224–2260. doi: 10.1016/S01406736(12)61766-8.Hovi P, Vohr B, Ment LR, et al. Blood Pressure in Young Adults Born at Very Low Birth Weight: Adults Born Preterm International Collaboration. Hypertension. 2016;68(4):880–887. doi: 10.1161/HYPERTENSIONAHA.116.08167.Hovi P, Vohr B, Ment LR, et al. Blood Pressure in Young Adults Born at Very Low Birth Weight: Adults Born Preterm International Collaboration. Hypertension. 2016;68(4):880–887. doi: 10.1161/HYPERTENSIONAHA.116.08167.Hovi P, Andersson S, Eriksson JG, et al. Glucose regulation in young adults with very low birth weight. N Engl J Med. 2007;356(20):2053–2063. doi: 10.1056/NEJMoa067187.Hovi P, Andersson S, Eriksson JG, et al. Glucose regulation in young adults with very low birth weight. N Engl J Med. 2007;356(20):2053–2063. doi: 10.1056/NEJMoa067187.Johansson S, Iliadou A, Bergvall N, et al. Risk of high blood pressure among young men increases with the degree of immaturity at birth. Circulation. 2005;112(22):3430–3436. doi: 10.1161/CIRCULATIONAHA.105.540906.Johansson S, Iliadou A, Bergvall N, et al. Risk of high blood pressure among young men increases with the degree of immaturity at birth. Circulation. 2005;112(22):3430–3436. doi: 10.1161/CIRCULATIONAHA.105.540906.Willemsen RH, de Kort SWK, van der Kaay DCM, HokkenKoelega ACS. Independent effects of prematurity on metabolic and cardiovascular risk factors in short small-for-gestational-age children. J Clin Endocrinol Metab. 2008;93(2):452–458. doi: 10.1210/jc.2007-1913.Willemsen RH, de Kort SWK, van der Kaay DCM, HokkenKoelega ACS. Independent effects of prematurity on metabolic and cardiovascular risk factors in short small-for-gestational-age children. J Clin Endocrinol Metab. 2008;93(2):452–458. doi: 10.1210/jc.2007-1913.Singhal A, Cole TJ, Lucas A. Early nutrition in preterm infants and later blood pressure: two cohorts after randomised trials. Lancet. 2001;357(9254):413–419. doi: 10.1016/S01406736(00)04004-6.Singhal A, Cole TJ, Lucas A. Early nutrition in preterm infants and later blood pressure: two cohorts after randomised trials. Lancet. 2001;357(9254):413–419. doi: 10.1016/S01406736(00)04004-6.Stritzke A, Thomas S, Amin H, et al. Renal consequences of preterm birth. Mol Cell Pediatr. 2017;4(1):2. doi: 10.1186/s40348016-0068-0.Stritzke A, Thomas S, Amin H, et al. Renal consequences of preterm birth. Mol Cell Pediatr. 2017;4(1):2. doi: 10.1186/s40348016-0068-0.

The authors declare that there are no conflicts of interest present.