<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rospedj</journal-id><journal-title-group><journal-title xml:lang="ru">Российский педиатрический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Pediatric Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2687-0843</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15690/rpj.v3i2.2422</article-id><article-id custom-type="elpub" pub-id-type="custom">rospedj-542</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL INVESTIGATIONS</subject></subj-group></article-categories><title-group><article-title>Влияние латентного дефицита железа и его последующей коррекции на показатели функциональных возможностей мальчиков-подростков</article-title><trans-title-group xml:lang="en"><trans-title>The Role of Latent Iron Deficiency and Its Subsequent Correction in Adolescent Boys' Functional Performance</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6000-1959</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шадрина</surname><given-names>И. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Shadrina</surname><given-names>I. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шадрина Инна Лерьевна</p><p>443112, Самара, п. Управленческий, ул. Крайняя, д. 17</p><p>eLibrary SPIN: 5330-3851</p></bio><bio xml:lang="en"><p>Inna L. Shadrina, MD</p><p>eLibrary SPIN: 5330-3851</p><p>17 Krainyaya Str., 443112, Samara</p></bio><email xlink:type="simple">7gbshadrina@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5766-6741</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Балашова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Balashova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Балашова Елена Анатольевна, доктор медицинских наук, доцент, доцент кафедры госпитальной педиатрии </p><p>443099, Самара, ул. Чапаевская, 89</p><p>eLibrary SPIN: 3556-3090</p></bio><bio xml:lang="en"><p>Elena A. Balashova, MD, PhD</p><p>eLibrary SPIN: 3556-3090</p><p>Samara</p></bio><email xlink:type="simple">e.a.balashova@samsmu.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Самарская городская больница № 7</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Samara City Hospital № 7</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Самарский ГМУ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Samara State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>28</day><month>09</month><year>2022</year></pub-date><volume>3</volume><issue>2</issue><fpage>387</fpage><lpage>395</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шадрина И.Л., Балашова Е.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Шадрина И.Л., Балашова Е.А.</copyright-holder><copyright-holder xml:lang="en">Shadrina I.L., Balashova E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rospedj.ru/jour/article/view/542">https://www.rospedj.ru/jour/article/view/542</self-uri><abstract><sec><title>Обоснование</title><p>Обоснование. Дефицит железа остается наиболее частым нутриентным дефицитом в мире. Его негативное влияние на физическое и психомоторное развитие определяет необходимость быстрой и полной его коррекции. Тем не менее, клиническая эффективность саплементации железа и ее влияние на функциональные возможности организма, особенно при латентном дефиците железа (ЛДЖ), остаются малоизученными.</p><p>Цель исследования — выявить влияние саплементации железа в различной дозировке на функциональные возможности здоровых мальчиков-подростков с учетом первоначального уровня запасов железа.</p></sec><sec><title>Методы</title><p>Методы. Проведено обследование мальчиков-подростков 12–17 лет I–II групп здоровья, обучающихся в Самарском кадетском корпусе. По результатам обследования (ОАК, уровень сывороточного ферритина) дети разделены на группы: основная — 20 детей с дефицитом железа (3 ребенка с выявленной железодефицитной анемией (ЖДА) не включены в анализ для данной статьи), контрольная — 99 детей. Все дети получали препараты железа в течение 30 дней: при ЛДЖ — 2,5 мг/кг/сут, здоровые — 15 мг/сут.</p></sec><sec><title>Результаты</title><p>Результаты. После 30 дней приема препарата железа нормализация уровня сывороточного ферритина произошла только у 75% (16) детей. Среднее время пробы Генчи составило 20" (16 ± 25) у здоровых и 17,5" (11,25 ± 21,75) при дефиците железа (р = 0,081). В группе ЛДЖ отмечается тенденция к удлинению времени задержки дыхания на выдохе после саплементации (р = 0,068). Время восстановления частоты сердечных сокращений до саплементации по результатам пробы Мартине – Кушелевского составило 118,8 ± 71,7" в основной и 168,0 ± 98,5" в контрольной группе (р = 0,045) и после саплементации уменьшилось в только основной группе (р = 0,009). Мышечная сила детей групп сравнения не отличалась до (р = 0,486) и после (р = 0,567) саплементации, однако в контрольной группе увеличилась относительно первоначальных значений (р = 0,003). До саплементации показатели физической подготовленности в группах не отличались. После саплементации в основной группе достоверно улучшились показатели времени бега на 60 м (р = 0,038). В контрольной группе обнаружена положительная динамика в отношении трех показателей: подтягиваний из виса на высокой перекладине (р = 0,019), прыжка в длину (р = 0,026) и бега на 60 м (0,018). При этом различий между основной и контрольной группами после саплементации не обнаружено.</p></sec><sec><title>Заключение</title><p>Заключение. Дефицит железа оказывает умеренное негативное влияние на адаптивные возможности дыхательной и сердечно-сосудистой систем и утомляемость. Саплементация железа при дефиците железа преимущественно улучшает показатели сердечно-сосудистой системы, при нормальных запасах железа — показатели мышечной силы и физической подготовленности.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. Iron deficiency remains the most frequent nutrient deficiency in the world. Its negative impact on the physical and psychomotor development determines the importance of its timely, fast, and complete correction. Thus, the clinical efficacy of iron supplementation and its effect on body function, especially in latent iron deficiency (LID), is still insufficiently studied.</p></sec><sec><title>Objective</title><p>Objective. The aim of the study is to identify the effect of iron supplementation in various dosages on functional performance of healthy adolescent boys but considering the initial iron levels.</p></sec><sec><title>Methods</title><p>Methods. The study covered teenage boys 12–17 years old from I and II health groups studying in Samara Cadet Corps. All children were divided into groups according to the examination results (CBC, serum ferritin level): study group — 20 children with iron deficiency (3 children with iron deficiency anemia (IDA) were not included in this analysis), and the control group — 99 children. All children received iron supplements for 30 days: children with LID — 2.5 mg/kg/day, healthy children — 15 mg/day.</p></sec><sec><title>Results</title><p>Results. Normalization of serum ferritin was achieved only in 75% (16) of children after 30 days of iron intake. The mean timed expiratory capacity was 20" (16 ± 25) in healthy and 17.5" (11.25 ± 21.75) in iron deficiency (p = 0.081) group. There is a tendency to prolong the breath retention time on exhalation after supplementation in LID group (p = 0.068). The recovery time of heart rate before supplementation was 118.8 ± 71.7" in study group and 168.0 ± 98.5" in control group (p = 0.045) according to the results of the Martin – Kushelevsky test. After supplementation it has decreased only in study group (p = 0.009). The children's muscle strength in compared groups did not differ before (p = 0.486) and after (p = 0.567) supplementation, however, it has increased in the control group regarding the initial values (p = 0.003). Physical fitness indicators in both groups did not differ before supplementation. Study group significantly improved the running time by 60 m (p = 0.038) after supplementation. Control group has shown positive dynamics for three indicators: pulling out from suspension on high bar (p = 0.019), long jump (p = 0.026), and running at 60 m (0.018). Moreover, there were no differences between study and control groups after supplementation.</p></sec><sec><title>Conclusion</title><p>Conclusion. Iron deficiency has moderate negative effect on adaptive respiratory and cardiovascular capabilities and fatigue. Iron supplementation mainly improves the indicators of cardiovascular system in case of iron deficiency, and indicators of muscle strength and physical fitness in case of normal iron levels.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>подростки</kwd><kwd>дефицит железа</kwd><kwd>состояние здоровья</kwd><kwd>функциональные возможности</kwd></kwd-group><kwd-group xml:lang="en"><kwd>adolescents</kwd><kwd>iron deficiency</kwd><kwd>health condition</kwd><kwd>functional performance</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено при финансовой поддержке Губернского гранта в области науки и техники Самарской области.</funding-statement><funding-statement xml:lang="en">The study was carried out with the financial support of the Provincial grant in the field of science and technology of Samara region.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">UNICEF. Non-communicable diseases. April 2021. In: UNISEF for every child. Available online: https://data.unicef.org/topic/childhealth/noncommunicable-diseases. Accessed on Marth 30, 2022.</mixed-citation><mixed-citation xml:lang="en">UNICEF. Non-communicable diseases. April 2021. In: UNISEF for every child. Available online: https://data.unicef.org/topic/childhealth/noncommunicable-diseases. Accessed on Marth 30, 2022.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Kassebaum NJ, Jasrasaria R, Naghavi M, et al. A systematic analysis of global anemia burden from 1990 to 2010. Blood. 2014;123(5):615– 624. doi: https://doi.org/10.1182/blood-2013-06-508325</mixed-citation><mixed-citation xml:lang="en">Kassebaum NJ, Jasrasaria R, Naghavi M, et al. A systematic analysis of global anemia burden from 1990 to 2010. Blood. 2014;123(5):615– 624. doi: https://doi.org/10.1182/blood-2013-06-508325</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">World Health Organization. Nutritional anaemias: tools for effective prevention and control. Geneva: World Health Organization; 2017.</mixed-citation><mixed-citation xml:lang="en">World Health Organization. Nutritional anaemias: tools for effective prevention and control. Geneva: World Health Organization; 2017.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Захарова И.Н., Тарасова И.С., Васильева Т.М. и др. Латентный дефицит железа у детей и подростков: диагностика и коррекция // Лечение и Профилактика. — 2018. — Т. 8. — № 1. — С. 69–75.</mixed-citation><mixed-citation xml:lang="en">Zakharova IN, Tarasova IS, Vasilyeva TM, et al. Nonanemic iron deficiency in children and adolescents: diagnosis and correction. Disease Treatment and Prevention. 2018;8(1):69–75. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Захарова И.Н., Мачнева Е.Б. Дефицит железа у подростков и его коррекция препаратами железа // Эффективная фармакотерапия. — 2014. — № 3. — С. 30–36.</mixed-citation><mixed-citation xml:lang="en">Zakharova IN, Machneva YeB. Iron deficiency and its treatment with iron preparations in adolescents. Effektivnaya farmakoterapiya. 2014;(3):30–36. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Дурманов Н.Д., Филимонов А.С. Диагностика и коррекция нарушений обмена железа в спорте высших достижений: методические рекомендации для врачей клубов. — М.; 2010.</mixed-citation><mixed-citation xml:lang="en">Durmanov ND, Filimonov AS. Diagnostika i korrektsiya narushenii obmena zheleza v sporte vysshikh dostizhenii: Guidelines for club doctors. Moscow; 2010. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">McCann S, Perapoch Amado M, Moore SE. The Role of Iron in Brain Development: A Systematic Review. Nutrients. 2020;12(7):2001. doi: https://doi.org/10.3390/nu12072001</mixed-citation><mixed-citation xml:lang="en">McCann S, Perapoch Amado M, Moore SE. The Role of Iron in Brain Development: A Systematic Review. Nutrients. 2020;12(7):2001. doi: https://doi.org/10.3390/nu12072001</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Чекалова Н.Г., Матвеева Н.А., Силкин Ю.Р. и др. Методы исследования и оценки функциональных резервов организма детей и подростков: методические указания. Н. Новгород: Изд-во НижГМА; 2009.</mixed-citation><mixed-citation xml:lang="en">Chekalova NG, Matveeva NA, Silkin YuR, et al. Metody issledovaniya i otsenki funktsional’nykh rezervov organizma detei i podrostkov: Guidelines. Nizhny Novgorod: Publishing House of the Nizhny Novgorod State Medical Institute; 2009. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Toblli JE, Brignoli R. Iron(III)-hydroxide polymaltose complex in iron deficiency anemia / review and meta-analysis. Arzneimittelforschung. 2007;57(6A):431–438. doi: https://doi.org/10.1055/s-0031-1296692</mixed-citation><mixed-citation xml:lang="en">Toblli JE, Brignoli R. Iron(III)-hydroxide polymaltose complex in iron deficiency anemia / review and meta-analysis. Arzneimittelforschung. 2007;57(6A):431–438. doi: https://doi.org/10.1055/s-0031-1296692</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Agaoglu L, Torun O, Unuvar E, et al. Effects of iron deficiency anemia on cognitive function in children. Arzneimittelforschung. 2007;57(6A):426–430. doi: https://doi.org/10.1055/s-0031-1296691</mixed-citation><mixed-citation xml:lang="en">Agaoglu L, Torun O, Unuvar E, et al. Effects of iron deficiency anemia on cognitive function in children. Arzneimittelforschung. 2007;57(6A):426–430. doi: https://doi.org/10.1055/s-0031-1296691</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Iron. Fact sheet for health professionals. Recommended Intakes. In: National Institutes of Health Office of Dietary Supplements. April 5, 2022. Available online: https://ods.od.nih.gov/factsheets/Iron-HealthProfessional/#h2. Accessed on August 06, 2022.</mixed-citation><mixed-citation xml:lang="en">Iron. Fact sheet for health professionals. Recommended Intakes. In: National Institutes of Health Office of Dietary Supplements. April 5, 2022. Available online: https://ods.od.nih.gov/factsheets/Iron-HealthProfessional/#h2. Accessed on August 06, 2022.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Гордеева О.Б., Ботвиньева В.В. Современные представления о железодефицитной анемии у детей и оптимизация лечения // Медицинский Cовет. — 2014. — № 6. — С. 59–65. — doi: https://doi.org/10.21518/2079-701X-2014-6-59-65</mixed-citation><mixed-citation xml:lang="en">Gordeyeva OB, Botvinyeva VV. Current views on iron deficiency anemia in children and treatment optimization. Meditsinskiy sovet = Medical Council. 2014;(6):59–65. (In Russ). doi: https://doi.org/10.21518/2079-701X-2014-6-59-65</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Жаркова Л.П. Обоснование выбора препарата железа для лечения железодефицитных состояний в педиатрии // Фарматека. — 2015. — № 1. — С. 16–22.</mixed-citation><mixed-citation xml:lang="en">Zharkova LP. Rationale for the choice of iron preparations for the treatment of iron deficiency in pediatrics. Farmateka. 2015;(1):16–22. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Li N, Zhao G, Wu W, et al. The Efficacy and Safety of Vitamin C for Iron Supplementation in Adult Patients With Iron Deficiency Anemia: A Randomized Clinical Trial. JAMA Netw Open. 2020;3(11):e2023644. doi: https://doi.org/10.1001/jamanetworkopen.2020.23644</mixed-citation><mixed-citation xml:lang="en">Li N, Zhao G, Wu W, et al. The Efficacy and Safety of Vitamin C for Iron Supplementation in Adult Patients With Iron Deficiency Anemia: A Randomized Clinical Trial. JAMA Netw Open. 2020;3(11):e2023644. doi: https://doi.org/10.1001/jamanetworkopen.2020.23644</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Гаврюшин М.Ю., Сазонова О.В., Бородина Л.М. и др. Физическое развитие детей и подростков школьного возраста: учебное пособие. — М.: Изд-во «Перо»; 2019.</mixed-citation><mixed-citation xml:lang="en">Gavryushin MYu, Sazonova OV, Borodina LM, et al. Fizicheskoe razvitie detei i podrostkov shkol’nogo vozrasta: uchebnoe posobie. Moscow: Pero; 2019. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Апанасенко Г.Л. Оценка физического развития детей и подростков с позиций биоэнергетики // Валеология. — 2003. — № 1. — С. 14–19.</mixed-citation><mixed-citation xml:lang="en">Apanasenko GL. Otsenka fizicheskogo razvitiya detei i podrostkov s pozitsii bioenergetiki. Journal of Health and Life Sciences. 2003;(1):14–19. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Александров А.А., Кисляк О.А., Леонтьева И.В. Клинические рекомендации. Диагностика, лечение и профилактика артериальной гипертензии у детей и подростков // Системные гипертензии. — 2020. — Т. 17. — № 2. — С. 7–35. — doi: https://doi.org/10.26442/2075082X.2020.2.200126</mixed-citation><mixed-citation xml:lang="en">Aleksandrov AA, Kisliak OA, Leontyeva IV. Clinical guidelines on arterial hypertension diagnosis, treatment and prevention in children and adolescents. Systemic Hypertension. 2020;17(2):7–35. (In Russ). doi: https://doi.org/10.26442/2075082X.2020.2.200126</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Чернов В.М., Тарасова И.С. Железодефицитная анемия // Детская гематология: клинические рекомендации / под ред. А.Г. Румянцева, А.А. Масчана, Е.В. Жуковской. — М.: ГЭОТАР-Медиа; 2015.</mixed-citation><mixed-citation xml:lang="en">Chernov VM, Tarasova IS. Zhelezodefitsitnaya anemiya. In: Detskaya gematologiya: Clinical guidelines. Rumyantseva AG, Maschan AA, Zhukovskaya EV, eds. Moscow: GEOTAR-Media; 2015. (In Russ).</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Тарасова И.С., Чернов В.М. Латентный дефицит железа у детей и подростков: состояние проблемы и перспективы развития // Педиатрический вестник Южного Урала. — 2020. — № 2. — С. 24–35. — doi: https://doi.org/10.34710/Chel.2020.98.13.003</mixed-citation><mixed-citation xml:lang="en">Tarasova IS, Chernov VM. Iron deficiency without anemia in children and adolescents: state of the problem and development prospects. Pediatric Bulletin of the South Ural. 2020;(2):24–35. (In Russ). doi: https://doi.org/10.34710/Chel.2020.98.13.003</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Zimmermann MB, Chassard C, Rohner F, et al. The effects of iron fortification on the gut microbiota in African children: a randomized controlled trial in Cote d’Ivoire. Am J Clin Nutr. 2010;92(6):1406– 1415. doi: https://doi.org/10.3945/ajcn.110.004564</mixed-citation><mixed-citation xml:lang="en">Zimmermann MB, Chassard C, Rohner F, et al. The effects of iron fortification on the gut microbiota in African children: a randomized controlled trial in Cote d’Ivoire. Am J Clin Nutr. 2010;92(6):1406– 1415. doi: https://doi.org/10.3945/ajcn.110.004564</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Mielgo-Ayuso J, Zourdos MC, Calleja-Gonzalez J, et al. Eleven Weeks of Iron Supplementation Does Not Maintain Iron Status for an Entire Competitive Season in Elite Female Volleyball Players: A Follow-Up Study. Nutrients. 2018;10(10):1526. doi: https://doi.org/10.3390/nu10101526</mixed-citation><mixed-citation xml:lang="en">Mielgo-Ayuso J, Zourdos MC, Calleja-Gonzalez J, et al. Eleven Weeks of Iron Supplementation Does Not Maintain Iron Status for an Entire Competitive Season in Elite Female Volleyball Players: A Follow-Up Study. Nutrients. 2018;10(10):1526. doi: https://doi.org/10.3390/nu10101526</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Rubeor A, Goojha C, Manning J, White J. Does Iron Supplementation Improve Performance in Iron-Deficient Nonanemic Athletes? Sports Health. 2018;10(5):400–405. doi: https://doi.org/10.1177/1941738118777488</mixed-citation><mixed-citation xml:lang="en">Rubeor A, Goojha C, Manning J, White J. Does Iron Supplementation Improve Performance in Iron-Deficient Nonanemic Athletes? Sports Health. 2018;10(5):400–405. doi: https://doi.org/10.1177/1941738118777488</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Tolkien Z, Stecher L, Mander AP, et al. Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: a systematic review and meta-analysis. PLoS One. 2015;10(2):e0117383. doi: https://doi.org/10.1371/journal.pone.0117383</mixed-citation><mixed-citation xml:lang="en">Tolkien Z, Stecher L, Mander AP, et al. Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: a systematic review and meta-analysis. PLoS One. 2015;10(2):e0117383. doi: https://doi.org/10.1371/journal.pone.0117383</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Лебедев В.В., Демихов В.Г., Фомина М.А. и др. Метод комплексной оценки продуктов окислительной модификации белков для определения безопасности двух и трехвалентных пероральных препаратов железа и их эффективности в лечении железодефицитной анемии у детей // Педиатрия. Журнал им. Г.Н. Сперанского. — 2018. — Т. 97. — № 5. — С. 47–53. — doi: https://doi.org/10.24110/0031-403X-2018-97-5-47-53</mixed-citation><mixed-citation xml:lang="en">Lebedev VV, Demikhov VG, Fomina MA, et al. A method for the complex evaluation of proteins oxidative modification products for determination of bivalent and trivalent oral iron preparations and their efficacy in iron deficiency anemia treatment in children. Pediatria. Journal n.a. G.N. Speransky. 2018;97(5):47–53. (In Russ). doi: https://doi.org/10.24110/0031-403X-2018-97-5-47-53</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Yasa B, Agaoglu L, Unuvar E. Efficacy, Tolerability, and Acceptability of Iron Hydroxide Polymaltose Complex versus Ferrous Sulfate: A Randomized Trial in Pediatric Patients with Iron Deficiency Anemia. Int J Pediatr. 2011;2011:524520. doi: https://doi.org/10.1155/2011/524520.</mixed-citation><mixed-citation xml:lang="en">Yasa B, Agaoglu L, Unuvar E. Efficacy, Tolerability, and Acceptability of Iron Hydroxide Polymaltose Complex versus Ferrous Sulfate: A Randomized Trial in Pediatric Patients with Iron Deficiency Anemia. Int J Pediatr. 2011;2011:524520. doi: https://doi.org/10.1155/2011/524520.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Мачнева Е.Б., Захарова И.Н., Тарасова И.С., Чернов В.М. Результаты рандомизированного исследования лечения железодефицитной анемии у детей и подростков с помощью железа (III) гидроксид полимальтозного комплекса и сульфата железа: критерии эффективности и переносимость // Вопросы гематологии/онкологии и иммунопатологии в педиатрии. — 2016. — Т. 15. — № 2. — С. 47–52. — doi: https://doi.org/10.20953/1726-1708-2016-2-47-52</mixed-citation><mixed-citation xml:lang="en">Machneva EB, Zakharova IN, Tarasova IS, Chernov VM. Results of a randomized study of management of iron deficiency anaemia in children and adolescents using an iron (III) hydroxide polymaltose complex and iron sulfate: criteria of efficacy and tolerance. Voprosy gematologii/onkologii i immunopatologii v pediatrii = Pediatric Haematology/Oncology and Immunopathology. 2016;15(2):47–52. (In Russ). doi: https://doi.org/10.20953/1726-1708-2016-2-47-52</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">de Alvarenga Antunes CV, de Alvarenga Nascimento CR, Campanha da Rocha Ribeiro T, et al. Treatment of iron deficiency anemia with liposomal iron in inflammatory bowel disease: efficacy and impact on quality of life. Int J Clin Pharm. 2020;42(3):895–902. doi: https://doi.org/10.1007/s11096-020-01044-x</mixed-citation><mixed-citation xml:lang="en">de Alvarenga Antunes CV, de Alvarenga Nascimento CR, Campanha da Rocha Ribeiro T, et al. Treatment of iron deficiency anemia with liposomal iron in inflammatory bowel disease: efficacy and impact on quality of life. Int J Clin Pharm. 2020;42(3):895–902. doi: https://doi.org/10.1007/s11096-020-01044-x</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Duque X, Martinez H, Vilchis-Gil J, et al. Effect of supplementation with ferrous sulfate or iron bis-glycinate chelate on ferritin concentration in Mexican schoolchildren: a randomized controlled trial. Nutr J. 2014;13:71. doi: https://doi.org/10.1186/1475-2891-13-71</mixed-citation><mixed-citation xml:lang="en">Duque X, Martinez H, Vilchis-Gil J, et al. Effect of supplementation with ferrous sulfate or iron bis-glycinate chelate on ferritin concentration in Mexican schoolchildren: a randomized controlled trial. Nutr J. 2014;13:71. doi: https://doi.org/10.1186/1475-2891-13-71</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Poveda C, Pereira DIA, Lewis M, Walton GE. The Impact of Low-Level Iron Supplements on the Faecal Microbiota of Irritable Bowel Syndrome and Healthy Donors Using In Vitro Batch Cultures. Nutrients. 2020;12(12):3819. doi: https://doi.org/10.3390/nu12123819</mixed-citation><mixed-citation xml:lang="en">Poveda C, Pereira DIA, Lewis M, Walton GE. The Impact of Low-Level Iron Supplements on the Faecal Microbiota of Irritable Bowel Syndrome and Healthy Donors Using In Vitro Batch Cultures. Nutrients. 2020;12(12):3819. doi: https://doi.org/10.3390/nu12123819</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang H, Wang L, Li S, et al. Association of Iron Storage Markers with Metabolic Syndrome and Its Components in Chinese Rural 6–12 Years Old Children: The 2010–2012 China National Nutrition and Health Survey. Nutrients. 2020;12(5):1486. doi: https://doi.org/10.3390/nu12051486</mixed-citation><mixed-citation xml:lang="en">Zhang H, Wang L, Li S, et al. Association of Iron Storage Markers with Metabolic Syndrome and Its Components in Chinese Rural 6–12 Years Old Children: The 2010–2012 China National Nutrition and Health Survey. Nutrients. 2020;12(5):1486. doi: https://doi.org/10.3390/nu12051486</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Wang HH, Liao LN, Chang CW, et al. The alteration of ferritin and transferrin saturation under body mass index and blood pressure in first-time and regular male blood donors in Taiwan. Medicine (Baltimore). 2019;98(22):e15854. doi: https://doi.org/10.1097/MD.0000000000015854</mixed-citation><mixed-citation xml:lang="en">Wang HH, Liao LN, Chang CW, et al. The alteration of ferritin and transferrin saturation under body mass index and blood pressure in first-time and regular male blood donors in Taiwan. Medicine (Baltimore). 2019;98(22):e15854. doi: https://doi.org/10.1097/MD.0000000000015854</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Okuno K, Naito Y, Yasumura S, et al. Influence of dietary iron intake restriction on the development of hypertension in weanling prehypertensive rats. Heart Vessels. 2018;33(7):820–825. doi: https://doi.org/10.1007/s00380-018-1134-4</mixed-citation><mixed-citation xml:lang="en">Okuno K, Naito Y, Yasumura S, et al. Influence of dietary iron intake restriction on the development of hypertension in weanling prehypertensive rats. Heart Vessels. 2018;33(7):820–825. doi: https://doi.org/10.1007/s00380-018-1134-4</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Lindberg J, Norman M, Westrup B, et al. Lower systolic blood pressure at age 7 y in low-birth-weight children who received iron supplements in infancy: results from a randomized controlled trial. Am J Clin Nutr. 2017;106(2):475–480. doi: https://doi.org/10.3945/ajcn.116.150482</mixed-citation><mixed-citation xml:lang="en">Lindberg J, Norman M, Westrup B, et al. Lower systolic blood pressure at age 7 y in low-birth-weight children who received iron supplements in infancy: results from a randomized controlled trial. Am J Clin Nutr. 2017;106(2):475–480. doi: https://doi.org/10.3945/ajcn.116.150482</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Профилактические осмотры детей и распределение по группам здоровья детей в возрасте 0–17 лет // Росстат. 02.06.2021. Доступно по: https://rosstat.gov.ru/folder/13807. Ссылка активна на 30.03.2022.</mixed-citation><mixed-citation xml:lang="en">Profilakticheskie osmotry detei i raspredelenie po gruppam zdorov’ya detei v vozraste 0–17 let. In: Federal State Statistics Service. June 02, 2021. (In Russ). https://rosstat.gov.ru/folder/13807</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Lurbe E, Agabiti-Rosei E, Cruickshank JK, et al. 2016 European Society of Hypertension guidelines for the management of high blood pressure in children and adolescents. J Hypertens. 2016;34(10):1887– 1920. doi: https://doi.org/10.1097/HJH.0000000000001039</mixed-citation><mixed-citation xml:lang="en">Lurbe E, Agabiti-Rosei E, Cruickshank JK, et al. 2016 European Society of Hypertension guidelines for the management of high blood pressure in children and adolescents. J Hypertens. 2016;34(10):1887– 1920. doi: https://doi.org/10.1097/HJH.0000000000001039</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Kurnianto A, Kurniadi Sunjaya D, Ruluwedrata Rinawan F, Hilmanto D. Prevalence of Hypertension and Its Associated Factors among Indonesian Adolescents. Int J Hypertens. 2020;2020:4262034. doi: https://doi.org/10.1155/2020/4262034</mixed-citation><mixed-citation xml:lang="en">Kurnianto A, Kurniadi Sunjaya D, Ruluwedrata Rinawan F, Hilmanto D. Prevalence of Hypertension and Its Associated Factors among Indonesian Adolescents. Int J Hypertens. 2020;2020:4262034. doi: https://doi.org/10.1155/2020/4262034</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Archbold KH, Vasquez MM, Goodwin JL, Quan SF. Effects of sleep patterns and obesity on increases in blood pressure in a 5-year period: report from the Tucson Children’s Assessment of Sleep Apnea Study. J Pediatr. 2012;161(1):26–30. doi: https://doi.org/10.1016/j.jpeds.2011.12.034</mixed-citation><mixed-citation xml:lang="en">Archbold KH, Vasquez MM, Goodwin JL, Quan SF. Effects of sleep patterns and obesity on increases in blood pressure in a 5-year period: report from the Tucson Children’s Assessment of Sleep Apnea Study. J Pediatr. 2012;161(1):26–30. doi: https://doi.org/10.1016/j.jpeds.2011.12.034</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
